“ALG-1007 represents Allegro’s first exploratory drug beyond the retina. We recognize the need to bring in independent external expertise that complements our company’s strengths and are thrilled to have such an outstanding group of advisors as Drs. Lindstrom, Holland and Donnenfeld help shape and accelerate our clinical program for dry eye disease.”

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ALG-1001 (Luminate®,. Allegro Ophthalmics), an integrin antago- nist, is being studied as of QPI-1007 intravitreal injections in sub- jects with recent onset of  NOV-07 (Novaliq). SHP659 (Shire/Takeda, originally Parion). SHP606 (Shire/ Takeda).

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Somerly Filson. This website contains many kinds of images but only a few are being shown on the homepage or in search results. In addition to these picture-only galleries, you  ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease. ALG-1007 demonstrated a strong signal in an ex-U.S.

ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ® ), currently being developed for diabetic macular edema (DME) and intermediate dry age “Allegro is continuously exploring new ways to apply our anti-integrin portfolio to help improve patients’ vision, and ALG-1007 represents our first exploratory drug for the potential treatment of dry eye, a disease that adversely affects millions of Americans.” The corporate … “Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics.

Today, Allegro also announced that the results of its ALG-1007 ex-U.S. proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the

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ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. For more information, visit www.allegroeye.com .

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Sylentis’ SYL-1001. Ocugen’s OCU300 and OCU310. NOV-07 (Novaliq) BL-1230 (Bioline Rx) Palovarotene (Clementia/Ipsen) SI-614 (Seikagaku) 2019-05-14 · Allegro Ophthalmics Announces Positive Results of Ex-US Proof-of-Concept Trial with Integrin Inhibitor ALG-1007 for Dry Eye Disease – Associated Press IDRO (@IDROOhio) May 14, 2019 from Twitt… Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in phase 2 development outside the United States. The option payment totaling $50 million would be made in 2 tranches, with the first payment of $10 million upon signing. Allegro Ophthalmics today announced positive topline results of its U.S. Phase 2 study of risuteganib for the treatment of intermediate dry AMD. Leaning into its new name, Bausch Health is laying the groundwork for a pipeline expansion.
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“Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics. “These early results suggest that ALG-1007 improves the signs and symptoms of dry eye, a disease that affects millions of people globally, with symptoms that include scratchy, stinging or burning sensations, and pain or

proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated. Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the United States. The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing.


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proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). ALG-1007. 05.14.19.